Hemochron Signature Elite Whole Blood Microcoagulation System

The Hemochron Signature Elite is the comprehensive point-of-care coagulation monitoring system. Ideal for the wide variety of applications found in today’s busy health care facilities.

  • Regardless of sample type or clinical setting, Hemochron provides fast, accurate and reproducible results for clinical decision making
  • Cuvette-based technology that’s easy to learn and use, and measures to the laboratory standard of fibrin formation
  • We designed the Hemochron to be the only point-of-care coagulation system you need in your facility, by offering a broad test menu that includes ACT+, ACT-LR, PT, Citrate PT, APTT, and Citrate APTT
  • Full features for compliance and connectivity to maximize efficiency and ease regulatory challenges


Watch Hemochron Signature Elite Videos by selecting from the list below:

Hemochron Overview (3:06)
Hemochron Basic Operation (5:10)
Hemochron Performing a Patient Test (5:34)

Hemochron Performing Quality Control (6:42)

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Test menu

  • Activated Clotting Time (ACT+)
  • Activated Clotting Time-Low Range (ACT-LR)
  • Prothrombin Time (PT)
  • Citrate Prothrombin Time (Citrated PT)
  • Activated Partial Thromboplastin Time (APTT)
  • Citrated  Partial Thromboplastin Time (Citrate APTT)


CLSI Formatted Procedures

Accriva is pleased to provide CLSI Formatted Procedures solely for the convenience of our customers for downloading in an editable format.  Use of such documents copied from this Website is for informational and non-commercial or personal use only.  Any changes made to these procedures are the sole responsibility of the party making the changes and Accriva accepts no liability for any consequence arising from the modification of materials or information copied from this site.
The files below may be opened as “Read Only”.  To customize/edit the file, please save the file on your local drive with a different file name.

Activated Clotting Time (ACT +)
Activated Partial Thromboplastin Time (APTT)
Citrate Activated Partial Thromboplastin Time (Citrate APTT)

Low Range Activated Clotting Time (ACT-LR)

Hemochron Signature Elite Implementation Guide


  • Small Sample: Only 15uL used for sample measurement. Enables greater flexibility during sample collection from all patients (Adults and Neonates)
  • Fresh, whole blood and citrated whole blood sample applications
  • Self-contained waste channel reduces biohazards
  • Barcoded label provides traceability for product type, lot, and expiration date



  Cuvette     Intended Use     Specimen  
ACT-LR Monitors low to moderate heparin doses up to 2.5 units/mL of blood. Used in procedures such as cardiac catherization, Extracorporeal Membrane Oxygenation (ECMO), dialysis and Percutaneous Transluminal Coronary Angioplasty. Whole blood
ACT+ Monitors moderate to high levels of heparin (1-6 units/mL). Unaffected by aprotinin, hypothermia, and hemodilution. Whole blood
PT For performing a quantitative, one-stage prothrombin time. Venous or fingerstick samples
Citrate PT For performing a quantitative, one-stage prothrombin time. Citrated whole blood
APTT For performing a quantitative, one-stage APTT. For evaluation of low dose heparin anticoagulation (up to 1.5 units/mL of blood). Whole blood
Citrate APTT For performing a quantitative, one-stage APTT. For evaluation of low dose heparin anticoagulation (up to 1.5 units/mL of blood). Citrated whole blood



  • Easy to read display
  • Ethernet connectivity port
  • Integrated barcode reader
  • Automatic internal EQC and temperature verification
  • Scans and stores cuvette and QC lot information, PID and OIDs
  • LQC and EQC lockout
  • Connects to AegisPOC™, RALS®-Plus, and TELCOR QML®


directCheck® Whole Blood Quality Control:
Easy to use, unitized liquid quality controls for Hemochron Signature Jr. Cuvettes


directCheck Control

ACT Cuvette (JACT+)  
     Level 1 Control DCJACT-N
     Level 2 Control DCJACT-A
ACT-LR Cuvette (JACT-LR)  
     Level 1 Control DCJLR-N
     Level 2 Control DCJLR-A
PT Cuvette (J201)  
     Level 1 Control DCJPT-N
     Level 2 Control DCJPT-A
Citrate PT Cuvette  (J201C)  
     Level 1 Control DCJCPT-N
     Level 2 Control DCJCPT-A
APTT Cuvette (J103)  
     Level 1 Control DCJAPTT-N
     Level 2 Control DCJAPTT-A
Citrate APTT Cuvette (J103C)  
     Level 1 Control DCJCPT-N
     Level 2 Control DCJCAPTT-A