Hemochron Response Whole Blood Coagulation System

The Hemochron Response Whole Blood Coagulation System is a dual-well microprocessor controlled testing instrument that offers an extensive menu for monitoring anti-coagulation therapy. Combined with the RXDX® Dosing system module, it can provide information for patient dosing, leading to improved outcomes and improved blood utilization.


  • Gold Standard ACT Tube technology provides confidence in results
  • Comprehensive point-of-care coagulation menu standardizes testing and improves efficiencies
  • Dual test well capabilities for heparin dosing protocols and improved patient management
  • Enhanced data management features to assist with regulatory compliance

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Test menu

  • Celite® Activated Clotting Time (ACT)
  • Kaolin ACT
  • Glass Particulate Activated ACT
  • Heparin Response Test (HRT)
  • Protamine Response Test (PRT)
  • Protamine Dose Assay (PDAO)


CLSI Formatted Procedures

Accriva is pleased to provide CLSI Formatted Procedures solely for the convenience of our customers for downloading in an editable format.  Use of such documents copied from this Website is for informational and non-commercial or personal use only.  Any changes made to these procedures are the sole responsibility of the party making the changes and Accriva accepts no liability for any consequence arising from the modification of materials or information copied from this site.
The file below may be opened as “Read Only”.  To customize/edit the file, please save the file on your local drive with a different file name.

Response CLSI Procedure (ITC)


  • Room temperature storage
  • Sample Size: 0.4 mL to 2.0 mL (assay dependent)
  • Fresh whole blood or citrated blood sample
  • Barcoded test tubes support storage and tracking of test, lot and expiration date


Tube Monitors Tube Color
HRFTCA510 Heparin
P214 Low levels of heparin
R-HRT480P (celite)
R-480PK (kaolin)
Heparin response
R-PRT200 (celite)
R-PRT200K (kaolin)
Protamine response at low to moderate
levels of heparin
R-PRT400 (celite)
R-PRT400K (kaolin)
Protamine response at high levels of heparin
PDAO (celite)
PDAOK (kaolin)
Verification of heparin neutralization



  • Extensive point-of-care coagulation test menu
  • Results displayed as whole blood, plasma equivalent, or INR (for PT assay)
  • Two test wells
  • On-board, internal printer
  • Large, easy to read, illuminated display screen
  • Data storage, including 600 patient tests per well and 300 Quality Control (QC) tests per well
  • Stores Operator and Patient Identification numbers
  • Operator lockouts and QC lockout capabilities
  • Stores data and connects to most POC data management systems



Liquid Quality Control:

ITC offers whole blood quality controls for use with the Hemochron tube assays.

  Liquid Quality Control     Applicable Tube  
QCACT Hemochron Kaolin and Celite ACT (HRFTK and HRFTCA510)
DCP214-N Hemochron P214 – Level 1
DCP214-A Hemochron P214 – Level 2
RQCHRT Hemochron Heparin Response test tubes (R-HRT480P and R-HRT480PK)
RQCPRT Hemochron Protamine Response (R-PRT200, PRT200K, R-PRT400, R-PRT400K, PDAO, and PDAO)


Interface connectivity available through:

  • AegisPOC™
  • RALS®-Plus